Author  
Place of duty  
Title   암의 골전이 정도와 생화학적 표지자 사이의 정량적 관계 ( Quantitative Correlation between the Biochemical Markers and the Extent of Metastatin Bone Tumors )
Publicationinfo   1997 Jan; 029(02): 257-266.
Key_word   Metastatic bone disease, Pyridinoline, Deoxypyridinoline
Full-Text  
Abstract   Purpose: We investigated the usefulness of urinary pyridinoline(uPyr) and deoxypyridinoline(uDpyr) and serum osteocalcin as markers of bone metastasis, particularly focussing on quantitative correlation between the degree of bone metastasis and the level of biochemical markers. Materials and Methods: By using ELISA method we measured the levels of uPyr, uDpyr, and osteocalcin in 100 cancer patients of whom 58 patients had bone metastasis, 42 had no bone metastasis, and 44 control subjects. Results: There was a significant difference in uPyr level between the patients with bone metastasis and the patients without bone metastasis or control group (mean+-SD, 70.26+- 43.11 vs 38.93+-21.48 or 25.13+-8.81 nM/mM Creatinine, p<0.05). And uDpyr level showed more significant elevation in the patients with bone metastasis than in the patients without bone metastasis and in control group (12.63+-7.51 vs 6.44+-3.58 and 4.23+-1.70 nM/mM Creatinine p<0.05). Osteocalcin level showed no significant difference among groups. We could demonstrate a significant quantitative correlation between the extent of bone metastasis and the amount of uPyr (r=0.7482, p<0.001) or uDpyr (r=0.5992, p<0.001). Conclusion: uPyr and uDpyr were significantly increased in metastatic bone tumors and quantitatively correlated well with the extent of bone metastasis. Therefore we can use these two markers as an evidence of bone metastasis. Further studies are recommended to decide the usefulness of these markers in the early detection of bone metastasis and in the assessment of response to antiresorptive treatments.
저 자   김수경(Soo Kyung Kim),조덕수(Deok Soo Cho),백현선(Hyun Sun Baek),김세화(Se Hwa Kim),김민철(Min Chul Kim),신성혜(Sung Hye Shin),이영희(Young Hee Lee),박주흥(Joo Heung Park)